In such cases or situations, when trying to discern the likelihood of a drug interaction occurring between coadministered medications, clinicians may need to resort to this method of evaluation. About Us Disclaimer Contact Us. Toggle navigation. Please enter text to search. Search by Outlines. Set Search Limits. The Inhibitory Constant Ki and its Use in Understanding Drug Interactions Summary : The inhibitory constant Ki and the IC50 of a drug that is known to cause inhibition of a cytochrome P CYP enzyme have to do with the concentration needed to reduce the activity of that enzyme by half.
More specifically the Ki is reflective of the binding affinity and the IC50 is more reflective of the functional strength of the inhibitor for a drug. Since the Ki takes into account the IC50 is its calculation, the Ki is being reported more often by drug companies. For noncompetitive inhibition of enzymes, the Ki of a drug is essentially the same numerical value as the IC50, whereas for competitive and uncompetitive inhibition the Ki is about one-half that of the IC50's numerical value.
The smaller the Ki, the greater the binding affinity and the smaller amount of medication needed in order to inhibit the activity of that enzyme. If a Ki is much larger than the maximal drug concentrations that a patient is typically exposed to from typical dosing, then that drug is not likely to inhibit the activity of that enzyme.
Editor-in-Chief: Anthony J. Explanation If clinicians have not already started to encounter Ki's in the literature and product package inserts for medications, they will likely encounter them in the future. Guidance for Industry. September Clinical Pharmacology. Bristol-Myers Squibb. Princeton, NJ. April Predicting inhibitory drug-drug interactions and evaluating drug interaction reports using inhibition constants. Ann Pharmacother ; Comparison of inhibitory effects of the proton pump inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P activities.
Abbreviation » Term. Term » Abbreviation. Word in Term. Term » Abbr. Filter by: Select category from list What does KI mean? Popularity rank for the KI initials by frequency of use: KI 1 Couldn't find the full form or full meaning of KI?
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